debinzhang Even if images exported from Photoshop have large margins, you can set the mesh hull in Spine to align with the edges of the image. This allows you to remove the blank areas when packing textures from Spine or rotate them to achieve the most efficient packing results. Therefore, large margins in images exported from Photoshop are not usually a problem.
If you have other reasons for wanting to remove the margins after considering the above, please let us know.